A new study finds that POGZ, a protein already known for its role in neurodevelopmental conditions like White-Sutton syndrome, also plays an important role in breast cancer. In triple-negative breast cancer (TNBC) models, POGZ acted as both a tumor promoter and a metastasis suppressor by blocking a signaling pathway (TGFβ) that drives cancer cells to spread. Tumors with lower POGZ levels were more aggressive and migratory, and patients with low POGZ expression had worse clinical outcomes. These findings suggest POGZ helps restrain the early stages of cancer spread in one of the hardest-to-treat breast cancer subtypes.