This study found that a protein called TGM2 is elevated in radiation-resistant cervical cancer cells and helps tumors survive radiotherapy by interacting with POGZ to repair DNA damage caused by radiation. When TGM2 was reduced, POGZ’s ability to fix broken DNA strands was impaired, making cancer cells more sensitive to radiation. Overexpressing TGM2 had the opposite effect, conferring radioresistance — an effect that was reversed when POGZ was also knocked down. These findings, confirmed in mouse tumor models, identify the TGM2–POGZ interaction as a potential target for improving radiotherapy outcomes in cervical cancer.